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Correlation of serum and ascitic IL-12 levels with second-look laparotomy results and disease progression in advanced epithelial ovarian cancer patients
  1. N. Bozkurt*,
  2. K. Yuce*,
  3. M. Basaran*,
  4. S. Gariboglu,
  5. F. Kose and
  6. A. Ayhan*
  1. *Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey
  2. Immunology Laboratory, Hacettepe University Faculty of Medicine, Ankara, Turkey
  3. Department of Obstetrics and Gynecology, SSK Ankara Maternity Hospital, Ankara, Turkey
  1. Address correspondence and reprint requests to: Nuray Bozkurt, MD, Tirebolu Sokak 27/18 Omrumce Apt, O6550 Yukari Ayranci, Ankara, Turkey. Email: nmbozkurt{at}yahoo.com

Abstract

Forty-two consecutive patients with advanced epithelial ovarian cancer who underwent primary surgical treatment were evaluated. The control group comprised 21 patients who had undergone surgery associated with benign pathologies. Forty-one patients had stage III disease except one who had stage IV. Optimal debulking (<1 cm) was performed in all the patients who subsequently received chemotherapy. Based on the results of the second-look laparotomy and follow-up, the patients were divided into three groups: the first group had negative second-look laparotomy or no evidence of disease during follow-up (n = 21), the second group had positive second-look laparotomy or progressive disease (n = 21), and the third was the control group (n = 21). Interleukin-12 (IL-12) levels were measured in preoperative serum and intraoperative ascites samples for all the patients. The mean serum IL-12 levels (±SD) in serum (S) and ascites (A) were as follows: in the first group, S: 108.44 ± 76.40 pg/mL and A: 330.93 ± 125.25 pg/mL; in the second group, S: 51.80 ± 40.95 pg/mL and A: 206.89 ± 113.47 pg/mL; and in the control group, S: 36.55 ± 33.16 pg/mL and A: 93.62 ± 73.07 pg/mL (P = 0.01). In the patients with advanced ovarian cancer, IL-12 levels in serum and ascites were higher compared to the levels of the controls. Also, there was an inverse relationship between initial serum and ascitic IL-12 levels and disease progression.

  • ascites
  • interleukin-12
  • ovarian cancer
  • prognosis
  • serum

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