Article Text

Download PDFPDF
Expression of cyclin H in normal and cancerous endometrium, its correlation with other cyclins, and association with clinicopathologic parameters
  1. F. Kayaselcuk*,
  2. S. Erkanli,
  3. F. Bolat*,
  4. G. Seydaoglu,
  5. E. Kuscu§ and
  6. B. Demirhan
  1. *Department of Pathology, Adana Research and Medical Center, Baskent University, Adana, Turkey
  2. Department of Obstetrics and Gynecology, Adana Research and Medical Center, Baskent University, Adana, Turkey
  3. Department of Biostatistics, Cukurova University, Adana, Turkey
  4. §Department of Pathology, Baskent University, Ankara, Turkey
  5. Department of Obstetrics and Gynecology, Baskent University, Ankara, Turkey
  1. Address correspondence and reprint requests to: Dr Fazilet Kayaselcuk, Pathology Department, Adana Research and Medical Center, Baskent University, Yuregir 01250, Adana, Turkey. Email: faziletks{at}


Cyclins are known as regulatory proteins in cell cycle. Cyclin H is a part of cyclin H/Cdk7/Mat1 complex, which is necessary for cellular proliferation. This study was designed to investigate the correlation of cyclin H expression with tumorigenesis of the endometrium and clinicopathologic variables. Immunohistochemical staining using labeled streptavidin–biotin complex was performed on formalin-fixed, paraffin-embedded endometrial tissues of the proliferative, hyperplastic, and carcinomatous types. Immunostaining for cyclins A, B1, D1, D3, E, H, and cyclin dependent kinase 2 were evaluated. The expression of cyclins A, D1, D3, and H in hyperplasia was significantly more frequent than those of proliferative phase and less than those of endometrioid adenocarcinoma. The expression of cyclin H was correlated with lymphvascular space invasion and clinical stage in carcinoma but not with myometrial invasion, lymph node metastasis, and menopause status. The expression of cyclin H could be involved in the transformation of the endometrium into malignancy and might be a marker for more proliferative and malignant features. It might be one of the biomarkers for determining proliferative activity in endometrial hyperplasia and endometrioid adenocarcinoma.

  • cyclin H
  • endometrial carcinoma
  • hyperplasia

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.