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Aggressive angiomyxoma of the female pelvis and perineum: a case series
  1. P. M. Magtibay*,
  2. Z. Salmon,
  3. G. L. Keeney and
  4. K. C. Podratz§
  1. *Department of Obstetrics and Gynecology, Mayo Clinic, Scottsdale, Arizona
  2. Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minnesota
  3. Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota
  4. §Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota
  1. Address correspondence and reprint requests to: Paul M. Magtibay, MD, Department of Obstetrics and Gynecology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA. Email: magtibay.paul{at}


Aggressive angiomyxoma (AA) was first described in 1983, and fewer than 150 cases have been reported in the world medical literature. These tumors are benign, locally infiltrative mesenchymal neoplasms with a predilection for the female pelvis and perineum and a tendency to recur. The size of AAs at presentation varies considerably; however, these tumors often achieve large dimensions before becoming clinically symptomatic. Surgical excision remains the mainstay of treatment, but whether clear, tumor-free surgical margins are necessary is controversial. We report a cohort of six patients treated surgically during the past 20 years for primary or recurrent AA. Treatment, surgical margin status, estrogen and progesterone receptor status, and outcomes are reviewed.

  • angiomyxoma
  • estrogen receptor
  • progesterone receptor

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