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HER-2 codon 655 polymorphism in cervical carcinogenesis
  1. M. Ueda*,
  2. Y.-C. Hung,
  3. Y. Terai*,
  4. J. Saito,
  5. O. Nunobiki,
  6. S. Noda and
  7. M. Ueki*
  1. *Department of Obstetrics and Gynecology, Osaka Medical College, Osaka, Japan
  2. Department of Obstetrics and Gynecology, China Medical College, Taichung, Taiwan
  3. Osaka Cancer Prevention Center, Osaka, Japan
  1. Address correspondence and reprint requests to: Masatsugu Ueda, MD, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan. Email: gyn017{at}


HER-2 codon 655 polymorphism together with human papillomavirus (HPV) types were examined in a total of 279 cervical smear samples. Forty-nine patients with high-grade squamous intraepithelial lesion had higher frequency of high-risk HPV than 167 patients with low-grade squamous intraepithelial lesion and 63 controls. There was no statistical difference in the frequencies of HER-2 Ile/Ile, Ile/Val, and Val/Val genotypes between squamous intraepithelial lesions (SILs) and controls. When the Ile/Ile genotype was compared to the Ile/Val + Val/Val genotypes, there was also no statistical difference in the genotype prevalence between SILs and controls either in 91 or 188 patients with or without high-risk HPV, respectively. These results suggest that the HER-2 polymorphism at codon 655 in cervical cell samples is unlikely to be associated with HPV status and the onset of cervical cancer in a Japanese population.

  • cervical carcinogenesis
  • HER-2
  • polymorphism
  • SIL

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