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Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review
  1. L. J. MCNEILAGE*,
  2. J. MORGAN*,
  3. J. CONSTABLE and
  4. T. W. JOBLING*
  1. *Gynaecological Oncology Unit, Monash Medical Centre, Melbourne, Australia
  2. Department of Pathology, Monash Medical Centre, Melbourne, Australia
  1. Address correspondence and reprint requests to: Dr L. Jane McNeilage, Gynaecological Oncology Unit, Moorabbin Campus, Monash Medical Centre, 865 Centre Road, Bentleigh East, Victoria 3165, Australia. Email: jmac01{at}


Primary malignant melanoma arising inform the ovary is rare, with only 30 cases described in the literature to date. The case reported here occurred in a 19-year-old woman and was rapidly progressive, resulting in death only 37 days following initial presentation. Management of this case is discussed in the context of the other reported cases. Surgery, ranging from an ovarian cystectomy to a radical debulking procedure, has been the main treatment with adjuvant chemotherapy utilized in only 4 of the previous cases. Key problems in management relate to the ability to make the diagnosis at the time of surgery and the overall poor response rates of melanoma to adjuvant chemotherapy.

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