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BASIC SCIENCE
Epstein–Barr virus plays little role in cervical carcinogenesis in Korean women
  1. S. S. Seo*,
  2. W. H. Kim†,
  3. Y. S. Song‡,
  4. S. H. Kim‡,
  5. J. W. Kim‡,
  6. N. H. Park‡,
  7. S. B. Kang‡ and
  8. H. P. Lee‡
  1. * Center for Uterine Cancer, National Cancer Center, Gyeonggi-do, Korea
  2. † Department of Pathology, Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea
  3. ‡ Department of Obstetrics and Gynecology, Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea
  1. Address correspondence and reprint requests to: Yong Sang Song, MD, Department of Obstetrics and Gynecology, Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongun-Dong, Chongno-Ku, Seoul 110-744, Korea. Email: yssong{at}snu.ac.kr

  1. Presented at the 54th Annual Meeting of the Japan Society of Obstetrics and Gynecology, Tokyo, Japan, April 6–9, 2002.

Abstract

We examined whether Epstein–Barr virus (EBV) infection plays a role in cervical carcinogenesis in Korean women. EBV infection was examined using polymerase chain reaction (PCR) with two different primer pairs flanking the BamHI “W” fragment of EBV and by EBV-encoded small RNAs (EBER) in situ hybridization in various histologic types of cervical cancer, including 17 cases of squamous cell carcinoma, 36 cases of adenocarcinoma, and 3 cases of small-cell carcinoma. We also evaluated 20 cases of cervical intraepithelial neoplasia and 20 cases of normal uterine cervix. One case of squamous cell carcinoma and three cases of cervical intraepithelial neoplasia were positive for EBV DNA using PCR, but EBER in situ hybridization analysis showed that none of the PCR-positive cases expressed EBER. EBV DNA was not found using PCR in any of the 20 normal uterine cervices. From our results, EBV infection does not seem to play a role in cervical carcinogenesis in Korean women.

  • cervical carcinoma
  • Epstein–Barr virus
  • Korean women

https://doi.org/10.1136/ijgc-00009577-200503000-00021

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