Article Text

Download PDFPDF
Increased cyclooxygenase-2 (COX-2) and P-glycoprotein-170 (MDR1) expression is associated with chemotherapy resistance and poor prognosis. Analysis in ovarian carcinoma patients with low and high survival
  1. M. R. Raspollini*,
  2. G. Amunni,
  3. A. Villanucci,
  4. V. Boddi and
  5. G. L. Taddei*
  1. * Department of Human Pathology and Oncology, University of Florence, Florence, Italy
  2. Department of Gynecology, Perinatology and Reproductive Medicine, University of Florence, Florence, Italy
  3. Department of Public Health, University of Florence, Florence, Italy
  1. Address correspondence and reprint requests to: Maria Rosaria Raspollini, MD, Department of Human Pathology and Oncology, University of Florence, viale GB Morgagni, 85, 50134 Florence, Italy. Email: mariarosaria.raspollini{at}


The aim of the study is to test the prognostic value of cyclooxygenase-2 (COX-2) and P-glycoprotein in relation to responsiveness to chemotherapy in ovarian carcinoma patients with “shorter and longer” survival. We evaluated 52 ovarian carcinomas homogeneous for stage, histologic type, grade of differentiation, and surgical and chemotherapeutic treatment. Twenty-eight of the patients had died of progression of disease no later than 2 years after primary surgical treatment, while 24 patients were alive with no evident disease 5 years after primary surgical treatment. In logistic regression analysis, COX-2 and P-glycoprotein, when analyzed one by one, are significant (P = 0.017 and P < 0.0005, respectively). P-glycoprotein is correlated with COX-2 (P = 0.008, Fisher's exact test); moreover, both COX-2 and the P-glycoprotein are correlated with clinical response to chemotherapy (P = 0.022 and P < 0.0005, respectively, Chi-square test). Our data suggest that COX-2 and P-glycoprotein may have prognostic significance in advanced ovarian serous carcinoma. The COX-2 and the P-glycoprotein overexpressions are correlated to one another and both with a progression of disease during the first-line chemotherapy. The administration of a COX-2 inhibitor in association with chemotherapy in ovarian carcinoma patients may improve the tumor chemosensibility and the overall survival.

  • chemoresistance
  • COX-2
  • MDR
  • ovarian carcinoma
  • P-glycoprotein
  • prognosis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.