Article Text

Download PDFPDF
Predictive value of serum interleukin-8 levels in ovarian cancer patients treated with paclitaxel-containing regimens
  1. R. Uslu*,
  2. U. A. Sanli*,
  3. Y. Dikmen,
  4. B. Karabulut*,
  5. A. Ozsaran,
  6. C. Sezgin*,
  7. G. G. Muezzinoglu*,
  8. S. B. Omay* and
  9. E. Goker*
  1. * Departments of Medical Oncology and Hematology, Ege University School of Medicine, Bornova, Izmir, Turkey
  2. Obstetrics and Gynecology, Ege University School of Medicine, Bornova, Izmir, Turkey
  1. Address correspondence and reprint requests to: Erdem Goker, MD, Department of Medical Oncology, Ege University School of Medicine, 35100 Bornova, Izmir, Turkey. Email: goker{at}


Previous findings showed that paclitaxel induces interleukin-8 (IL-8) transcription and secretion in ovarian cancer cells in vitro. We hypothesized that paclitaxel treatment, which is a standard care for ovarian cancer patients, may increase the secretion of IL-8, resulting in the elevated serum IL-8 levels. In this study, we investigated the relationship between paclitaxel exposure and IL-8 levels of an ovarian and a breast carcinoma cell line in vitro and serums of patients with ovarian carcinoma. Both MDAH 2774 ovarian and MCF-7 breast carcinoma cell lines were sensitive to paclitaxel-mediated cytotoxicity. However, supernatant levels of IL-8 assessed by enzyme-linked immunosorbent assay before and after treatment with different concentrations of paclitaxel were significantly lower in MCF-7 than in MDAH 2774. Serum IL-8 levels were measured in serum samples from patients with ovarian carcinoma before and after paclitaxel-containing treatment regimens. Forty-eight patients were included in the study. The basal level of IL-8 after paclitaxel-containing treatment was found to be significantly higher in the serums of patients who had high tumor burden than in patients who had optimal debulking surgery and low tumor burden. These data strongly suggest that IL-8 may be an important predictive marker for tumor volume as well as sensitivity to paclitaxel.

  • interleukin-8
  • MCF-7
  • MDAH 2774
  • paclitaxel

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.