Article Text

Download PDFPDF
Intraperitoneal hyperthermic chemotherapy in ovarian cancer
  1. J. Gori*,
  2. R. Castaño*,
  3. M. Toziano,
  4. D. HÄBICH*,
  5. J. Staringer,
  6. D. G.B. De Quirós§ and
  7. N. Felci
  1. * Department of Gynecology and Obstetrics, Hospital Alemán, Buenos Aires, Argentina
  2. Department of Gynecology, Hospital Naval, Buenos Aires, Argentina
  3. Department of Gynecology and Obstetrics, Hospital Español, Buenos Aires, Argentina
  4. § Department of Gynecology and Obstetrics, Clínica Independencia, Buenos Aires, Argentina
  1. Address correspondence and reprint requests to: Jorge R. Gori, MD, PhD, Jefe del Departamento de Ginecología y Obstetricia, Hospital Alemán, Av Pueytredón 1640, Buenos Aires, Argentina. Email: lprimavera{at}


We investigated the effect of intraperitoneal hyperthermic perfusion chemotherapy as consolidation therapy in stage IIIB–IIIC ovarian cancer, following cytoreductive surgery and systemic chemotherapy (cisplatin–cyclophosphamide—six cycles). Disease-free survival, overall survival, and side effects were compared with a control group of patients who refused a second-look surgery and intraperitoneal chemotherapy. In a multicenter prospective trial, 29 patients with complete or optimal cytoreductive surgery and systemic treatment were included in the consolidation group and received intraperitoneal hyperthermic perfusion chemotherapy. Patients were recruited between January 1991 and December 1997. The intraperitoneal hyperthermic perfusion was performed with open-abdomen technique, using physiologic solution containing cisplatin 100 mg/m2, for 60 min in hyperthermic phase (41–43°C). Intraperitoneal hyperthermic perfusion chemotherapy was locally and systemically well tolerated. The consolidation therapy group showed a better 5-year survival rate and lower recurrent disease rate, but differences were not statistically significant. Our results suggest that intraperitoneal hyperthermic perfusion chemotherapy is a feasible, well-tolerated, and promising alternative as consolidation therapy in ovarian cancer.

  • hyperthermia
  • intraperitoneal chemotherapy
  • ovarian cancer

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.