Article Text

Download PDFPDF
Aggressive angiomyxoma of the female genital tract: a clinicopathologic and immunohistochemical study of 12 cases
  1. C. A. Amezcua*,
  2. S. J. Begley,
  3. N. Mata,
  4. J. C. Felix*, and
  5. C. A. Ballard
  1. * Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA
  2. Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA
  1. Address correspondence and reprint requests to: Charles A. Ballard, Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, 1240 N. Mission Road, Rm. L1014, Los Angeles, CA 90033. Email: cballard{at}usc.edu

Abstract

Aggressive angiomyxoma (AAM) is a distinctive neoplasm seen in the female genital tract. We present the clinicopathological findings of 12 female patients with AAM. Immunohistochemical analysis for vimentin, desmin, smooth-muscle actin (SMA), muscle-specific actin (MSA), S-100, CD44, estrogen receptor (ER), and progesterone receptor (PR) was performed. Mean patient age was 39 years (range 20–77 years). Eight tumors arose in the vulva, two in the suburethral area, and two in the perirectal area. Three were pedunculated (two vulvar and one suburethral). Perineal tumors were locally excised, with limited removal of adjacent tissue or tissue surrounding the pedicle base of pedunculated tumors. Perirectal tumors were removed by wide excision. Tumors ranged 2.8–40.0 cm in size. Eleven patients were followed-up (mean 19 months). Recurrence occurred in one patient 48 months after tumor resection from perirectum and abdomen. Immunohistochemistry showed tumor positivity for vimentin (11/11), desmin (8/11), CD44 (8/11), ER (10/12), PR (11/12), and SMA (3/11). MSA and S-100 were negative. In summary, AAM in the perineum especially pedunculated tumors may possibly require only local excision for definitive treatment. Furthermore, the majority of AAM have CD44 expression.

  • aggressive angiomyxoma
  • CD44
  • desmin

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.