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Immunohistochemical expression of CD10 antigen in uterine adenosarcoma
  1. F. AMANT*,
  4. L. VERBIST*,
  5. V. M. Abeler,
  6. G. TULUNAY§,
  7. E. DE JONGE,
  8. L. MASSUGER**,
  9. P. MOERMAN and
  10. I. VERGOTE*
  1. *Division of Gynecological Oncology, Department of Obstetrics & Gynecology, University Hospitals Leuven, Leuven, Belgium
  2. Department of Pathology, University Hospitals Leuven, Leuven, Belgium
  3. Department of Pathology, The Norwegian Radium hospital, Oslo, Norway
  4. §Department of Gynecological Oncology, SSK Ankara Maternity and Women's Hospital, Ankara, Turkey
  5. Department of Obstetrics & Gynecology, Ziekenhuis Oost-Limburg, Genk, Belgium
  6. **Department of Obstetrics & Gynecology, University Hospital Nijmegen, St. Radboud, Nijmegen, The Netherlands
  1. Address correspondence and reprint requests to: F. Amant, Division of Gynecological Oncology, Department of Obstetrics & Gynecology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. Email: frederic.amant{at}


Uterine adenosarcoma (UAS) is microscopically characterized by a biphasic growth pattern. By definition, the epithelial component is benign, whereas the stromal component typically has the appearance of a low-grade sarcoma, usually an endometrial stromal sarcoma. CD10 acts by reducing cellular response to peptide hormones and is currently regarded as a specific marker for endometrial stromal tumors. In this international multicenter study, we further explored CD10 immunoreactivity in 30 UASs. We encountered CD10 positivity of the sarcomatous component in 18/20 (90%) of UASs, in five of eight (63%) of UASs with sarcomatous overgrowth as well as in both cases of recurrent UAS. The epithelial component stained negative in all cases. These findings suggest that CD10 can be used to differentiate UAS from cellular leiomyoma, or in case endometrial stromal cells exhibit muscle differentiation. Furthermore, CD10 positivity in recurrent UAS might guide the pathologist toward an endometrial stromal origin.

  • adenosarcoma
  • CD10
  • immunohistochemistry
  • stromal
  • uterus

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