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Is normal β-hCG regression curve helpful in the diagnosis of persistent trophoblastic disease?
  1. N. Behtash,
  2. F. Ghaemmaghami,
  3. H. Honar,
  4. K. Riazi,
  5. A. Nori,
  6. M. Modares and
  7. A. Mousavi
  1. Department of Gynecologic Oncology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
  1. Address correspondence and reprint requests to: N. Behtash, MD, Department of Gynecologic Oncology, Vali-e-Asr Hospital, Keshavarz Blvd, Tehran (14194), Iran. Email: nadbehtash2{at}


Objective The aim of this study was to evaluate the probable usefulness of normal β-human chorionic gonadotropin (β-hCG) regression curve in the diagnosis of persistent trophoblastic disease (PTD).

Methods A log-value regression curve was developed from the means and 95% confidence limits of serial weekly serum β-hCG titers of 43 patients with uneventful complete hydatidiform moles and 14 patients, who were previously confirmed as PTD.

Results All 14 PTD patients (100%) had abnormal values, beyond normal range, within 4 weeks. β-hCG was in its upper values, compared to normal regression curve at 2.29 ± 0.19 weeks. This was earlier than plateau or rise detection at 4.21 ± 0.33 weeks (P < 0.001). Within 3 weeks of evacuation, 13 of 14 (92.86%) PTD patients' β-hCG values exceeded the normal range, whereas only six of 14 (42%) showed a rise or plateau.

Conclusion Our finding indicates that the normal β-hCG regression curve may be useful for quicker detection of PTD than the plateau or rise of level.

  • human chorionic gonadotropin
  • persistent trophoblastic disease
  • regression curve

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