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Do the pelvic lymph nodes predict the parametrial status in cervical cancer stages IB–IIA?
  1. R. Puente*,
  2. S. Guzman*,
  3. E. Israel* and
  4. M. T. Poblete
  1. * Gynecologic Oncology Section, Institute of Obstetrics and Gynecology, Universidad Austral de Chile, Valdivia, Chile
  2. Institute of Histology and Pathology, Hospital Clínico Regional, Universidad Austral de Chile, Valdivia, Chile
  1. Address correspondence and reprint requests to: Prof. Raul Puente, Instituto de Obstetricia y Ginecología, Universidad Austral de Chile, Hospital Clínico Regional, Simpson 850, Valdivia, Chile. Email: rpuente{at}uach.cl

Abstract

The aim of this study was to determine whether the pelvic lymph nodes would predict the parametrial status in patients with cervical cancer stages IB1–IIA submitted to radical surgery and pelvic lymphadenectomy. To this end, we evaluated the relationship between positive and negative pelvic lymph nodes and their parametria. Our final purpose was to use this information to recommend the tailoring of the parametrial resection according to the status of pelvic lymph nodes to decrease the morbidity related with radical paratrectomy. From January 1996 to December 2001, 107 consecutive patients with cervical cancer stages IB1 and IIA were primarily treated by radical hysterectomy type III with systematic pelvic lymphadenectomy in a prospective study. Parametria were studied in two sections: the first included the tissue adjacent to the cervix, and the second the distal 2/3. Lymph nodes were routinary processed. Twenty-two patients (20.6%) had positive pelvic nodes and 16 patients (14.9%) had parametrial involvement, mostly by direct extension. Eight patients with positive pelvic nodes (36.4%) had parametrial involvement, whereas among 85 patients with negative pelvic nodes only eight patients (9.4%) had parametrial involvement (P < 0.001), most in internal parametria (62.5%). The sensitivity of pelvic lymph nodes for parametrial involvement was 50% and the positive predictive value was 36.4%, whereas the specificity was 84.6%; and the negative predictive value 90.6%. In the group of negative pelvic lymph nodes, only two patients (2.3%) had parametrial involvement beyond internal parametria. The univariated and multivariated analysis of prognostic factors was always significant but without a significant independent factor for positive parametria. Pelvic lymph nodes appear as good predictors of parametrial status, especially in node-negative patients, and could be used to decrease the paratrectomy in radical surgery.

  • cervical carcinoma
  • lymph node metastasis
  • parametrial involvement
  • radical hysterectomy

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