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Histopathologic parameters of prognosis in cervical cancer – a review
  1. N. Singh and
  2. S. Arif
  1. Department of Histopathology, St Bartholomew's Hospital, London, UK


Apart from clinical stage and lymph node status, acknowledged to be among the most powerful predictors of outcome in cervical cancer, the determination of prognosis and thereby the need for adjuvant therapy in surgically treated patients currently relies on a variety of histopathologic factors. The role of many of these is controversial. This may be because histopathology is genuinely lacking in sensitivity for predicting tumor behavior in vivo. There is, however, wide variation in histopathologic definitions and criteria. This is probably the major reason for both the lack of reproducibility in the reporting of certain factors and in their diminished value in predicting behavior. Tumor type, grade, vascular invasion, pattern of invasion, and depth are all extremely important prognostic indicators when used individually or as a part of a scoring system.

  • cervical cancer
  • depth
  • grade tumor type
  • grading systems
  • histopathology
  • margins
  • prognosis
  • stage
  • vascular invasion
  • volume

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  • Dr Naveena Singh, Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK. Email: n.singh{at}