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  • Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy

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ORIGINAL ARTICLES
Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy
  1. W.-S. Ahn*,
  2. D.-J. Kim†,
  3. G.-T. Chae‡,
  4. J.-M. Lee*,
  5. S.-M. Bae§,
  6. J.-I. Sin§,
  7. Y.-W. Kim§,
  8. S.-E. Namkoong* and
  9. I. P. Lee*
  1. * Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, South Korea
  2. † Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, South Korea
  3. ‡ Institute of Chronic Disease, College of Medicine, The Catholic University of Korea, Seoul, South Korea
  4. § Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea
  1. Address correspondence and reprint requests to: Dr Woong-Shick Ahn, MD, PhD, Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Ku, Seoul 137-040, South Korea. Email: ahnws{at}catholic.ac.kr

Abstract

A mushroom extract, Agaricus blazei Murill Kyowa (ABMK), has been reported to possess antimutagenic and antitumor effects. Here, we investigate the beneficial effects of ABMK consumption on immunological status and qualities of life in cancer patients undergoing chemotherapy. One hundred cervical, ovarian, and endometrial cancer patients were treated either with carboplatin (300 mg/m2) plus VP16 (etoposide, 100 mg/m2) or with carboplatin (300 mg/m2) plus taxol (175 mg/m2) every 3 weeks for at least three cycles with or without oral consumption of ABMK. We observed that natural killer cell activity was significantly higher in ABMK-treated group (ANOVA, n = 39, P < 0.002) as compared with nontreated placebo group (n = 61). However, no significant difference in lymphokine-activated killer and monocyte activities was observed in a manner similar to the count of specific immune cell populations between ABMK-treated and nontreated groups. However, chemotherapy-associated side effects such as appetite, alopecia, emotional stability, and general weakness were all improved by ABMK treatment. Taken together, this suggests that ABMK treatment might be beneficial for gynecological cancer patients undergoing chemotherapy.

  • alternative therapy
  • Agaricus blazei Murill Kyowa
  • gynecological cancer
  • quality of life

https://doi.org/10.1136/ijgc-00009577-200407000-00003

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