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Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review
  3. U. BELLER and
  4. J. J. KAVANAGH*
  1. *Department of Gynecologic Medical Oncology
  2. Department of Gynecologic Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
  3. Division of Gynecologic Oncology, Shaare Zedek Medical Center, Jerusalem, Israel
  1. Address correspondence and reprint requests to: John J. Kavanagh, MD, Department of Gynecologic Medical Oncology, Unit 401, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Email: jkavanag{at}


Many reports of ovarian, cervical, and uterine cancers metastatic to lung, liver, and brain have been published. A fewer number of them focused on the surgical treatment for these patients. We reviewed the published literature, regarding surgical management of metastatic disease in patients with gynecological cancer. Some prognostic factors in the patients with metastatic lesions from these three different cancers were found in common. Favorable prognostic factors for a prolonged survival were good performance status of the patients, long disease-free interval, absence of other systemic disease, and the resectability, preferably with a clear margin. These factors should be considered as the criteria for surgery. In well-selected patients, survival could be extended from the surgical procedure with minimal complications. Other types of treatment such as radiation therapy or chemotherapy could also be given in conjunction with surgery, depending on tumor type and disease status of the primary cancer, other systemic diseases, and residual metastatic lesions after surgery.

  • CNS
  • gynecological cancers
  • liver
  • lung
  • metastases
  • resection

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