Article Text

Download PDFPDF
Sulfatides in ovarian tumors: clinicopathological correlates
  1. A. M. Makhlouf*,
  2. M. M. Fathalla*,
  3. M. A. Zakhary and
  4. M. H. Makarem*
  1. * Department of Obstetrics and Gynecology, Assiut University Hospital, Assiut, Egypt
  2. Department of Biochemistry, Assiut University, Assiut, Egypt
  1. Address correspondence and reprint requests to: Makhlouf Ahmed Mohammad, Assistant Professor, Department of Obstetrics and Gynecology, Assiut University Hospital, Assiut, Egypt. Email: makhloufsalama{at}


Objectives To investigate the expression of sulfatides in the tissue homogenates of malignant ovarian tumors, benign ovarian tumors, and control tissues and to study the relation between this marker and other clinico-pathological criteria such as the tumor type, grade of differentiation, surgical stage and ovulatory years.

Design Cross-sectional study.

Setting Department of Obstetrics and Gynecology and Department of Biochemistry, Assuit university hospital.

Subjects Forty-six patients had malignant ovarian tumors. Sixteen patients had benign ovarian neoplasm. Thirty patients, with normal ovaries, represented the control group.

Methods A sample of the tumor or from the normal ovary (the control group) was sent for histopathological and biochemical examination. Sulfatides were measured by a rapid and sensitive spectrophotometric method.

Results There was a significant rise in benign tumors [median and range 43 (38–53)], than in the control group, 21 (18–31), P-value = 0.000. In malignant tumors, the median value of sulfatides was significantly higher than in benign tumors [127 (71–193), P-value = 0.000]. Sulfatides were significantly higher in patients with more ovulatory years and tumors of advanced stages (stage III/IV) and poor differentiation.

Conclusions Sulfatides may play a role in the pathogenesis of benign and malignant ovarian tumors. It may also predict advanced stages in patients who are apparently early stage. It is also a candidate to study of their association with response to chemotherapy.

  • malignancy
  • ovarian tumors
  • prediction
  • stage
  • sulfatides

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.