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Consolidation treatment of advanced ovarian carcinoma with radiotherapy after induction chemotherapy
  1. B. Sorbe
  1. Department of Gynecological Oncology, Örebro University Hospital, Örebro, Sweden
  1. Address correspondence and reprint requests to: B. Sorbe, Department of Gynecological Oncology, Örebro University Hospital, SE-701 85 Örebro, Sweden. Email: bengt.sorbe{at}


In a prospective randomized trial, consolidation treatment with radiotherapy or chemotherapy was compared with no treatment in a series of 172 patients with epithelial ovarian carcinoma, FIGO stage III, with complete surgical remission after primary cytoreductive surgery and induction chemotherapy. In the subgroup with complete pathological remission, progression-free survival (PFS) was significantly (P = 0.032) better in the radiotherapy group (56%) than in the chemotherapy group (36%) and the untreated control group (35%). The number of recurrences was lowest in the radiotherapy group. The overall relapse rate was reduced by 33% and the pelvic recurrences by 43% by consolidation radiotherapy. On the other hand, treatment-related side effects were more frequent in the radiotherapy group.

  • consolidation therapy
  • ovarian carcinoma
  • radiotherapy

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