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Optimal therapy of advanced ovarian cancer: carboplatin and paclitaxel versus cisplatin and paclitaxel (GOG158) and an update on GOG0182-ICON5
  1. M. A. Bookman*,
  2. B. E. Greer and
  3. R. F. Ozols*
  1. * Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA
  2. Division of Gynecologic Oncology, University of Washington School of Medicine, Seattle, WA
  1. Address correspondence and reprint requests to: Michael A. Bookman, MD, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. Email: ma_bookman{at}
  1. Presented in part as ‘Carboplatin–Paclitaxel versus Cisplatin-Paclitaxel and Update on GOG0182-ICON5’ at the 4th International Symposium, Advanced Ovarian Cancer: Optimal Therapy, Update, Valencia, Spain (28 February 2003).


Mature results from GOG158 have clearly established carboplatin and paclitaxel as an effective and well-tolerated standard regimen, providing a basis for the reference arm in GOG0182-ICON5, an ongoing multiarmed phase III trial of the Gynecologic Cancer InterGroup (GCIG) evaluating the incorporation of newer cytotoxic agents. Results from GOG158 will be reviewed, including an analysis of second-look surgical outcomes, followed by an update on the current status of GOG0182-ICON5.

  • carboplatin
  • ovarian cancer
  • paclitaxel
  • second-look

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