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Endometrial cancer metastasis presenting as a grossly swollen toe
  1. Z. A. Ali,
  2. J. A. Wimhurst,
  3. A. A. Ali,
  4. M. E. Tempest and
  5. D. J. Edwards
  1. Department of Trauma and Orthopaedics, Addenbrooke's Hospital NHS Trust, Cambridge, UK
  1. Address correspondence and reprint requests to: Z.A. Ali, MB, ChB (Hons), Registrar, 10 Sandringham Dr., Stockport, Cheshire SK4 2 DD, United Kingdom. Email: ziadali_md{at}


Metastasis to the peripheral skeleton, especially in the face of low stage disease, is rare. This report describes the case of a 77-year-old lady with stage IC disease who underwent curative total abdominal hysterectomy and bilateral salpingo-oopherectomy 2 years prior to presenting with a painless gigantism of her fourth toe. A histologic diagnosis of dedifferentiated endometrial metastasis with sarcomatous differentiation was made following amputation of the toe. Osseous metastasis to bone is discussed in the context of endometrial carcinoma and the literature reviewed. This paper reports the first case of endometrial carcinoma metastasis presenting as gross swelling of a toe.

  • bone
  • endometrial cancer
  • metastasis

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