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A real time optoelectronic device as an adjunct to the Pap smear for cervical screening: A multicenter evaluation
  1. A. Singer*,
  2. M. Coppleson,
  3. K. Canfell,
  4. V. Skladnev,
  5. G. Mackellar,
  6. N. Pisal* and
  7. A. Deery§
  1. * Department of Gynaecology, The Whittington Hospital, London, UK
  2. Department of Gynaecology, Royal Prince Alfred Hospital for Women and Babies, Sydney, Australia
  3. Department of Gynaecology, Polartechnics Limited, Sydney, Australia
  4. § Department of Gynaecology, The Royal Free Hospital, London, UK
  1. Address correspondence and reprint requests to: Professor Albert Singer, Department of Gynaecology, The Whittington Hospital, London N19 5NF, UK. E-mail: albert.singer{at}whittington.nhs.uk.

Abstract

We report on the results from a multicenter trial for a real time optoelectronic device as an adjunct to the Pap smear for cervical screening. TruScreen (Polartechnics Limited, Sydney, Australia) is an automated device which measures the response to optical and electrical stimulation of the cervix and returns a screening result in real time. Analysis was performed on a group of 651 subjects recruited at 10 centers. Cytology and histology analyses were performed by centralized laboratories, with the cytology classification performed according to the Bethesda 2001 system. The sensitivities for histologically confirmed CIN 2/3 lesions by TruScreen, Pap, and TruScreen/Pap combined were 70% (95% CI: 67–74), 69% (CI: 65–72), and 93% (CI: 91–95), respectively. For histologically reported CIN 1, the sensitivities of the TruScreen, Pap, and combined test were 67% (CI: 63–70), 45% (CI: 41–49), and 87% (CI: 84–89). The improvement in sensitivity for the combined test compared to the Pap smear alone was significant (P = 0.002). Because TruScreen and cytology detect partly different but overlapping groups of CIN cases, the adjunctive combination provides very high CIN detection rates.

  • cervical screening
  • optoelectronic device
  • real time screening

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Footnotes

  • Contributors: Albert Singer, Malcolm Coppleson and Karen Canfell designed the study, analyzed the results, and drafted the paper. Victor Skladnev and Geoff Mackellar were responsible for the design of the TruScreen expert system, and provided an encrypted output version of the device for the study. Narendra Pisal critically revised the paper. Alastair Deery provided centralized review readings for histologic results.

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