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Immunohistochemistry in gynecological pathology
  1. M. T. Deavers,
  2. A. Malpica and
  3. E. G. Silva
  1. Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
  1. Address correspondence and reprint request to: Michael T. Deavers, MD, Department of Pathology, Box 85, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030. Email: mdeavers{at}


Although the majority of diagnoses in gynecological pathology are established on examination of routine hematoxylin and eosin stained sections, additional tests are occasionally required. Immunohistochemistry is widely used to provide additional diagnostic information in problematic cases. This review touches on some of the basics of the procedure, presents an example immunohistochemical panel, and discusses some of the most common immunohistochemical markers used in diagnostic gynecological pathology. Differential diagnostic problems and relevant immunohistochemical stains for the vulva, vagina, cervix, uterus, and ovary are also addressed.

  • cervical neoplasms
  • immunohistochemistry
  • ovarian neoplasms
  • uterine neoplasm
  • vaginal neoplasms
  • vulvar neoplasms

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