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Epithelioid trophoblastic tumor (ETT) initially interpreted as cervical cancer
  1. F. Narita*,
  2. K. Takeuchi*,
  3. S. Hamana*,
  4. C. Ohbayashi,
  5. M. Ayata and
  6. T. Maruo*
  1. * Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
  2. Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
  3. Department of Pathology, Central Hospital, Hyogo, Japan
  1. Address correspondence and reprint requests to: Fukuko Narita, Department of Obstetrics and Gynecology, Kobe University, Graduate School of Medicine Kobe 650-0017, Japan. Email: naritafukuko{at}


The epithelioid trophoblastic tumor (ETT) is a rare form of trophoblastic disease and shows a wide spectrum of differential diagnoses and clinical behavior. A 53-year-old woman presented with ETT presumably originated in spontaneous delivery of 25 years ago and was initially diagnosed as cervical cancer on cervical punch biopsy followed by radical hysterectomy. The uterus showed a small tumor restricted to the cavum with no cervical infiltration, resembling ETT in histologic and immunohistochemical features. The difficulties and clues in distinguishing ETT from nontrophoblastic lesions are discussed.

  • epithelioid trophoblastic tumor
  • immunohistochemistry
  • squamous cell carcinoma

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