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REVIEW ARTICLES
Rodent models for ovarian cancer research
  1. K. D. Sloan Stakleff* and
  2. V. E. Von Gruenigen*,†,‡
  1. * Kenneth Calhoun Research Laboratory, Akron, Ohio USA
  2. † Department of Obstetrics and Gynecology, Akron General Medical Center, Akron, Ohio USA
  3. ‡ Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio USA

  • To whom correspondence and reprint requests should be addressed: Kimberly D. Sloan Stakleff, MS, Akron General Medical Center, Calhoun Research Laboratory, 400 Wabash Avenue, Akron, Ohio 44307. Email: kstakleff{at}agmc.org

Abstract

Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.

  • animal models
  • ovarian cancer
  • review

https://doi.org/10.1136/ijgc-00009577-200307000-00002

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