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Mixed choriocarcinoma in a postmenopausal patient
  1. L. M Ramondetta,
  2. C. F Levenback,
  3. T. W Burke and
  4. E. G Silva1
  1. 1 Departments of Gynecologic Oncology Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas


Abstract. Ramondetta LM, Silva EG, Levenback CF, Burke TW. Mixed choriocarcinoma in a postmenopausal patient.

Gestational trophoblastic disease rarely presents in patients beyond the reproductive years. To our knowledge, this is the first case of mixed trophoblastic disease in a postmenopausal woman. We present here a case of a 60-year-old woman with evidence of a pelvic mass and pulmonary metastasis. Surgery revealed an 8 x 6 x 6 cm multinodular uterine tumor involving the right adnexa. Histologic review was consistent with choriocarcinoma with intermediate trophoblastic features. Postoperative β-hCG was 381 561 mIU/ml.

We conclude that maintaining a high index of suspicion facilitates the identification of postmenopausal patients with metastatic gestational trophoblastic disease. This case reconfirms the deceptive presentation of the “great masquerader”.

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