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Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation
  1. A Ribeiro-Silva1,
  2. A Novello-Vilar1,
  3. A. M Cunha-Mercante1 and
  4. L. A. L De Angelo Andrade2
  1. 1 Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP/USP), and
  2. 2 Department of Anatomical Pathology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil


Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. Along with a brief review of this amazing neoplasm, some histogenetic concepts relevant to this case are discussed. To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.

  • cervix
  • chromogranin
  • immunohistochemistry
  • malignant mixed mullerian tumor

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