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Coexistence of metastatic neuroendocrine carcinoma of the uterine cervix with human immunodeficiency virus infection
  1. J. Balega1,
  2. T. M. Ulbright2 and
  3. K. Y. Look1
  1. 1 Departments of Obstetrics and Gynecology and
  2. 2 Pathology, Indiana University School of Medicine, Indianapolis, Indiana
  1. Address correspondence and reprint requests to: Katherine Y. Look, MD, Associate Professor, 535 Barnhill Drive, Room 434, Indianapolis IN 46202. E-mail: klook{at}


Abstract. Balega J, Ulbright TM, Look KY. Coexistence of metastatic neuroendorcine carcinoma of the uterine cervix with human immunodeficiency virus infection.

Women now constitute 28% of new cases of human immunodeficiency virus (HIV) infection. Cervical cancer in HIV-infected women has a high recurrence and death rate, as well as decreased intervals to recurrence and death. Neuroendocrine carcinomas of the cervix are characterized by a high frequency of early nodal and distant metastases.

We present the first report of a neuroendocrine carcinoma of the cervix in an HIV-positive patient. A 28 year old with a 9-year history of HIV succumbed to metastatic neuroendocrine carcinoma of the cervix 5 months after diagnosis.

Given the aggressive nature of the cell type, an extended metastatic workup should be considered prior to surgery. The immune suppression present in HIV-positive patients with neuroendocrine cervical carcinoma may make such a workup particularly crucial, such that surgery is offered only to those who can be expected to benefit.

  • HIV
  • neuroendocrine cervix cancer

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