You are here

Article Text

Article menu
Download PDFPDF
Original Articles
Distribution of HPV 53, HPV 73 and CP8304 in genital epithelial lesions with different grades of dysplasia
  1. T. Meyer,
  2. R. Arndt,
  3. E.-R. Beckmann,
  4. B. Padberg,
  5. E. Christophers and
  6. E. Stockfleth
  1. Institute of Immunology, Pathology and Molecular Biology (IPM) Hamburg, and Department of Dermatology, University of Kiel, Germany
  1. Address correspondence or reprint requests: T. Meyer, Institute of Immunology, Pathology and Molecular Biology, Lademannbogen 61, 22339 Hamburg, Germany. E-mail: meyer{at}labor-keeser-arndt.de.

Abstract

To characterize the risk of malignant progression of cervical epithelial lesions associated with human papillomavirus (HPV) types of yet unknown oncogenic potential the prevalences of these HPVs in different cervical epithelial lesions of 809 patients were determined. HPV types 53, 73, and CP8304 were detected in genital specimens of 16, 22, and 12 of the patients, respectively. The ratio of prevalence in high grade dysplastic lesions or cancers and low grade dysplastic lesions or normal specimens was calculated and compared to corresponding values of well known high-risk (HR) and low-risk (LR) HPVs. For HPV 6, 11, 16, 18, 35, and 73 a ratio of 0.1, 0.2, 5.9, 6.5, 2.5, and 2.4, respectively, was calculated. The ratios of HPV53 and CP8304 were less than 1. Moreover, in contrast to HPV73, these viruses have never been detected in cancer specimens. Thus, HPV53 and CP8304 infections are probably not associated with a high risk of carcinogenesis, while HPV73 could be another HR-HPV type.

  • cervical cancer
  • dysplasia
  • HPV
  • oncogenic
  • prevalence

https://doi.org/10.1136/ijgc-00009577-200105000-00006

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.