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Epidemiologic and mucosal immunologic aspects of HPV infection and HPV-related cervical neoplasia in the lower female genital tract: A review
  1. M. Y. Tjiong1,2,3,
  2. T. A. Out3,4,
  3. J. Ter Schegget2,
  4. M. P. M. Burger1 and
  5. N. Van Der Vange5
  1. 1Departments of Obstetrics and Gynecology
  2. 2Virology
  3. 3Clinical and Laboratory Immunology Unit, Academic Medical Center
  4. 4CLB, Sanquin Blood Supply Foundation
  5. 5Department of Gynecology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  1. Address correspondence and reprint requests to: Dr. N. Van der Vange, Department of Gynecology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Email: vdvange@nki nl. Supported by European Cancer Center, Amsterdam, The Netherlands.


Human papillomavirus (HPV) infections are known to play an important role in the pathogenesis of cervical neoplasia. Considering the morbidity and mortality of cervical cancer, infection with HPV can be regarded as a worldwide problem, especially in developing countries. Currently, many studies focus on the development of both prophylactic and therapeutic HPV vaccines. Crucial for these vaccination protocols to be successful is that they will result in a long-lasting ability to generate an immune response that will eliminate the virus. HPV transmission and subsequent infection is a local event in the lower female genital tract and therefore the efficacy of vaccines against this locally transmitted infection can be best assessed by parameters of local immunity. In this review we describe both the epidemiology of HPV-related cervical neoplasia and the general aspects of mucosal immunity in the female genital tract while focusing on the local humoral immunity in HPV-related cervical neoplasia.

  • cervical neoplasia
  • HPV
  • mucosal immunology

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