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Phase II study of vindesine in disseminated squamous cell carcinoma of the uterine cervix: an EORTC Gynecological cancer Cooperative Group study
  1. J. B. VERMORKEN*,
  2. F. LANDONI,
  4. M. J. PICCART§,
  5. M. E. L. VAN DER BURG,
  7. M. GEORGE††,
  8. S. GREGGI‡‡ and
  9. N. ROTMENSZ§§
  1. *Department of Oncology, Free University Hospital, Amsterdam
  2. Department of Obstetrics & Gynecology, Ospedale S. Gerardo, Monza
  3. Clin Obstet & Gynecol Università, Spedali Civili, Brescia
  4. §Institut fules Bordet, Brussels
  5. Dr Daniel den Hoed Cancer Center, Rotterdam
  6. **Netherlands Cancer Institute, Amsterdam
  7. ††Institut Gustave Roussy, Villejuif
  8. ‡‡Department of Obstetrics & Gynecology, University of Cattolica S. Cuore, Rome
  9. §§EORTC Data Center, Brussels
  1. Address for correspondence: J.B. Vermorken, MD, PhD, Department of Oncology, Free University Hospital De Boele-laan 1117, 1081 HV Amsterdam, The Netherlands.


Twenty-nine patients with disseminated squamous cell carcinoma of the uterine cervix were treated with a 3 mg/m2 weekly i.v. bolus schedule of vindesine for 6 weeks (thereafter every 2 weeks). Twenty-seven patients were evaluable for response, 19 of whom had received prior chemotherapy (14 also vincristine). Five of the 27 patients (19%) showed a partial response, all being part of the 22 patients with only distant metastases. No objective response were observed among five patients who also had loco-regional recurrent disease. The median duration of response was 21 (11–58) weeks. Dose-limiting toxic effects were leukopenia and peripheral neuropathy. Vindesine warrants further study in combination chemotherapy protocols for cervical cancer.

  • carcinoma of the cervix
  • phase 11
  • squamous cell
  • vindesine

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