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Plasminogen activators in endometrial adenocarcinoma
  1. N. Gleeson,
  2. R. Gonsalves,
  3. E. McGuinness and
  4. J. Bonnar
  1. Trinity College Department of Obstetrics & Gynaecology, Dublin, Ireland
  1. Address for correspondence: H. Lee Cancer Center, University of South Florida, 12902 Magnolia Drive, Florida 33612-9497, USA


There are two disinct types of plasminogen activator, tissue type (t-PA) and urokinase (u-PA). We measured t-PA and u-PA antigen levels in extracts of 14 endometrial adenocarcinoma and of seven normal postmenopausal endometria. The concentration of endometrial t-PA was higher in normal than in malignant uteri (p <0.05). In endometrial carcinoma t-PA levels were higher in less invasive disease. Endometrial u-PA levels were very low or absent in normal postmenopausal uteri and significantly higher (p < 0.001) in malignant cases. An increase in u-PA and a decrease in t-PA are features of malignant transformation of the endometrium.

  • adenocarcinoma
  • endometrium
  • tissue plasminogen activator (t-PA)
  • urokinase (u-PA)

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