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Original Article
Detection of human papillomavirus DNA in cervical smears by the polymerase chain reaction
  1. C. CHETSANGA‡,
  2. B. PETTERSSON†,
  3. U. PETTERSSON* and
  4. U. GYLLENSTEN*
  1. *Department of Medical Genetics, Uppsala University
  2. †Department of Gynecologic Oncology, University Hospital, Uppsala, Sweden
  3. ‡Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe
  1. Address for correspondence: *Department of Medical Genetics, Biomedical Center, Box 589, S-75123 Uppsala, Sweden.

Abstract

A PCR-based method has been developed which allows human papillomavirus DNA to be detected in routinely obtained cervical smear specimens. The results showed that 76% of the smears that were collected from women who were carrying HPV-positive lesions by cervical swab analysis were positive by the PCR-based method. The results suggest that it is possible to carry out population-based retrospective studies of archival cervical smears.

  • cervical smear
  • cervix neoplasm
  • human papillomavirus
  • polymerase chain reaction

http://dx.doi.org/10.1111/j.1525-1438.1991.tb00042.x

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    1991 International Gynecological Cancer Society and the European Society of Gynaecological Oncology