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Histochemical distribution of CA-125 as a prognostic indicator in patients with serous ovarian cancer
  1. P. BICHEL*,
  2. A. JAKOBSEN and
  3. T. F. ØRNTOFT
  1. *Institute of Pathology, Vejle Central Hospital and University Institute of Pathology
  2. Department of Oncology
  3. Department of Clinical Chemistry, Aarhus Kommunehospital, and Department of Experimental Clinical Oncology, the Danish Cancer Society, Denmark
  1. Address for correspondence: P. Bichel, University Institute of Pathology, Aarhus Kommune-hospital, DK-8000 Aarhus C, Denmark


The study comprises 66 patients with stage III and IV serous ovarian carcinomas of whom 64 had CA-125 positive tumors.

While the percentage of CA-125 positive cells and the staining intensity showed no correlation to patient survival, the pattern of CA-125 distribution, membranous versus cytoplasmic, was significantly correlated to survival. In accordance with other observations on switching of the antigen reaction from membrane to cytoplasm with increasing grade of atypia or malignancy, patients with membrane positive CA-125 tumors had a significantly better prognosis than did patients with CA-125 in the cytoplasm.

Furthermore, there was excellent agreement between, on the one hand, the binding pattern of CA-125 and, on the other, the ploidy of the tumor cells and the HGI histopathologic grading index, both previously shown to be of prognostic significance.

  • CA-125
  • histochemical distribution
  • ovary carcinoma
  • prognosis

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