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Prognostic factors in the treatment of stage 1B adenocarcinoma of the cervix
  1. Kankipati Shanti Raju1,
  2. Kjell E. Kjorstad* and
  3. Vera Abeler*
  1. 1 Departments of Gynaecological Oncology, Oslo, Norway
  2. * Pathology, The Norwegian Radium Hospital, Oslo, Norway
  1. Address for correspondence: Dr K.S. Raju, Department of Gynaecology, St Thomas' Hospital, London SE17EH, U.K. KSR was awarded the Bernard Barron Fellowship by the Royal College of Obstetricians and Gynaecologists U.K. to visit The Norwegian Radium Hospital.

Abstract

One hundred and fifty-seven patients with Stage 1B adenocarcinoma treated between 1955 and 1986 in the Norwegian Radium Hospital were studied. Of these 136 patients had radical hysterectomy and pelvic lymphadenectomy and 21 simple total abdominal hysterectomy and bilateral salpingo-oophorectomy. One hundred and eleven patients had pre-operative brachytherapy. Histological grade of tumor (P < 0.001) lymph node metastasis (P < 0.001) and residual tumor in the surgical specimen 4–6 weeks after brachytherapy (P < 0.001) had a significant prognostic effect on the recurrence and survival irrespective of the extent of surgery and radiotherapy. Lymph node involvement was directly related to histological grade of the tumor (P < 0.0001).

  • adenocarcinoma of cervix
  • prognosis
  • recurrence
  • survival
  • treatment.

https://doi.org/10.1111/j.1525-1438.1991.tb00018.x

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