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Prognostic factors in uterine cervical carcinoma: a clinicopathological analysis
  1. R. J. Hale*,2,
  2. F. L. Wilcox*,
  3. C. H. Buckley1,
  4. V. R. Tindall,
  5. W. D.J. Ryder and
  6. J. P. Logueh
  1. 1 Department of Histopathology, St Mary's Hospital, Manchester
  2. 2 Department of Histopathology, St Mary's Hospital, Manchester M13 0JH, UK.
  3. University Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester
  4. * Department of Obstetrics and Gynaecology, Royal Victoria Hospital, Blackpool
  5. Department of Medical Statistics, Christie Hospital and Holt Radium Institute, Manchester, UK
  6. Department of Radiotherapy and Oncology, Christie Hospital and Holt Radium Institute, Manchester, UK


A clinicopathological analysis of 235 patients with stage IB/IIA cervical carcinoma was performed. These patients represent all those treated between 1975 and 1989 inclusive by primary Wertheim's hysterectomy at St Mary's Hospital, Manchester. We found that a significantly higher proportion of tumors from patients under 40 years of age contained mucin and that overall the adenosquamous carcinomas had a significantly greater incidence of lymph node metastases (P= 0.00049). Pelvic lymph node metastases had no effect on prognosis in these adenosquamous carcinomas but did in squamous carcinomas (P= 0.0004) and adenocarcinomas (P= 0.0001). Univariate log-rank analysis showed that variables associated with survival were: pregnancy at diagnosis (P= 0.0238), lymphatic permeation (P < 0.0001), vascular permeation (P < 0.0001), lymph node metastases (P < 0.0001), tumor volume (P < 0.0001), canal length of tumor (P= 0.0009), cervical stromal tumor-free rim (P= 0.0027), parametrial extension (P= 0.0008) and adequacy of excision (P= 0.0389). In a multivariate regression analysis (Cox's regression model) lymphatic permeation, tumor volume, pregnancy at diagnosis and lymph node metastases were independent prognostic variables.

  • cervical carcinoma
  • prognostic factors.

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