Introduction/Background Report one case of ovavian carcinoma metastasis breast mimicking the primary breast carcinoma

Methodology Case report and review literature

Results Breast is an uncommon metastatic site of ovarian cancer with only 0.03 – 0.6% of all breast maglinancies. There are only 110 cases documented until 2015. The rarity of this circumstance can lead to insufficent diagnosis and overtreatment. The case in our report was the 55-year old female. She had the breast tumor, ovarian tumor and supraclavicular lymph node. The H&E images of all tumor showed adenoma carcinoma. We performed IHC stain eight markers, including WT1, PAX8, P16, p53, ER, PR, Mamma-globulin and Ki67. All tumor had the similar results with this panel markers. Detailly, WT1, PAX8, P16, p53, ER were positive and PR, Mamma-globulin were negative. According to these results, we concluded this was the case of ovarian carcinoma metastasis to breast and supraclavicular lymph node.

Conclusion Surgical pathology and Immunohistochemistry play an important role in our case of determining the origin of the metastatic lesion of the breast therefore they give us precise diagnosis and staging. Sufficient assessment of this patient give us the reasonable mangement orientation without any overzealous treatment.