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Translational research biomarkers
65 The prognostic significance of eukaryotic translation initiation factors (eIFs) in ovarian cancer
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  1. M Sobočan1,2,
  2. S Sprung3,
  3. C Schatz3,
  4. J Knez1,2,
  5. R Kavalar2,4,
  6. I Takač2,4 and
  7. J Haybaeck3,5
  1. 1University Medical Centre Maribor, Division for Gynaecology and Perinatology, Maribor, Slovenia
  2. 2University of Maribor , Faculty of Medicine, Maribor, Slovenia
  3. 3Medical University of Innsbruck, Institute of Pathology, Neuropathology and Molecular Pathology, Innsbruck, Austria
  4. 4University Medical Centre Maribor, Department of Pathology, Maribor, Slovenia
  5. 5Medical University Graz, Diagnostic and Research Center for Molecular BioMedicine, Department of Neuropathology, Diagnostic and Research Institute of Pathology, Graz, Austria

Abstract

Introduction/Background*Ovarian cancer represents the most lethal gynaecological cancer. Although treatment options for patients with ovarian cancer have expanded, many patients suffer from disease relapse early after primary treatment. Different targeted therapies based on signalling pathways in ovarian cancer have yielded limited clinical success warranting the evaluation of further biological targets to improve therapy precision. A potential target is the machinery of protein synthesis, facilitated by eukaryotic initiation factors (eIFs). However, little is known about the role of eIFs in ovarian cancer. The aim of this study was to evaluate the role of different eIFs and their correlation to clinical outcome in ovarian cancer patients.

Methodology We performed immunohistochemical staining for the 6 eIF subunits (eIF1A1, eIF2alpha, eIF2G, eIF5A, eIF5B and eIF6) from samples of women diagnosed with epithelial ovarian cancer (EOC) at the University Medical Centre Maribor, Slovenia between January 2009 and December 2014. For all samples, a composite score of density and intensity of expression was calculated. Expression data was assessed in correlation to recurrence free survival (RFS) and overall patient survival (OS). The statistical analysis was performed using the Spearman rank correlation.

Result(s)*The cohort consisted of 75 women with EOC with a mean age of 61.2 years (SD 11.15). Disease specific death occurred in 74% of women (n=56) and disease recurred in 61% (n=47) women. The eIF subunit eIF5A (rs=-.234, p<0.043) was found to be correlated with overall survival and recurrence free survival (rs=-.247, p>0.033) in patients with EOC. An overexpression of eIF5A was significantly correlated with RFS (U=496.5, p>0.017) and OS (U=398.0, p>0.006).

Conclusion*Further evaluation of the initiation translation cascade in ovarian cancer and specifically the impact the expression of eIF5A has on EOC may be warranted. eIF5A may serve as a prognostic marker in EOC.

https://doi.org/10.1136/ijgc-2021-ESGO.587

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