Introduction/Background*Ovarian cancer (OC) is the most lethal gynaecological malignancy worldwide. In general, patients face a poor prognosis due to the fact that they often have an advanced stage of disease at diagnosis. The peak incidence is seen at 65 to 70 years and only a small group of women is diagnosed under 40 years of age. Younger women have better overall survival compared to older women but prognostic factors and evolution are not well stablished.

Methodology Retrospective analysis of women under 45 years old diagnosed of epithelial and non-epithelial ovarian cancer during the last 10 years.

Result(s)*25 women under 45 years with OC were reviewed. Mean age at diagnosis was 36.27 years (SD 5.77; min:21, max: 43). Most of the tumors (52% N:13) were epithelial serous OC (Clear cells: 20.0% N:5; Endometrioid: 12.0 N:3; Mucinous: 8.0% N:2; Endodermal sinus: 4.0% N:1; Granulosa cell: 4.0% N: 1). Most of the patients were diagnosed in advanced tumoral stages (III-IV: 68.0%, N:17). Appropriate surgery and chemotherapy was applied individually in each case. After a long period of follow up (6-108 months) 50% of women were death (medium follow up for alive women: 66.44 months (SD: 26.93; min: 24; max: 108 months; medium follow up for death women: 23.60 months; SD: 14.45; min:6; max: 41 months). Mean time of relapse was 14.33 moths (SD: 12.30; min: 4; max: 45 months), mostly in abdominal location (92.85% N: 13), that were treated with quemotherapy (85.71% N:12) and surgery (28.75% N:4). After relapse only 20.0% were disease free (N:3) while 2 patients died and 60.0% (N: 15) were alive with disease.

Conclusion*Ovarian cancer in premenopausal women is a threatening condition, diagnosed in most cases in advanced stages, with a high probability of bad prognosis despite appropriate surgical and oncologic management.