You are here

Article Text

Article menu

Download PDFPDF

Poster
IGCS20_1473
435 Palliative electrochemotherapy in vulvar cancer: a double institution study and review of the literature
Free
  1. G Corrado1,
  2. G Cutillo2,
  3. S Fragomeni1,
  4. V Bruno2,
  5. L Tagliaferri3,
  6. E Mancini2,
  7. C Certelli2,
  8. E Vizza2,
  9. G Scambia1 and
  10. G Garganese1
  1. 1Gynaecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli – IRCCS, Italy
  2. 2Gynaecologic Oncology Unit, IRCCS ‘Regina Elena’ National Cancer Institute, Italy
  3. 3Radioterapia Oncologica ed Ematologia – Gemelli ART (Advanced Radiation Therapy), Interventional Oncology Center (IOC), Fondazione Policlinico Universitario A. Gemelli – IRCCS, Italy

Abstract

Introduction The aim of this study is to revise the experience of two reference centers for vulvar cancer treatment during the last 2 years, evaluating the ECT procedure in terms of clinical outcome and side effects profile.

Methods Data were retrospectively collected from November 2017 to November 2019 in two Italian oncologic Institutes: Regina Elena Institute and Fondazione Policlinico Universitario Agostino Gemelli. ECT was offered in a palliative setting to patients with a primary or recurrent vulvar cancer diagnosis unsuitable for surgery or any other treatment, because of poor performance status or previous delivered treatments. All patients underwent general anaesthesia. Intravenous Bleomycin was administered. Follow-up examinations were performed at 1, 3 and 6 months.

Results 15 patients were included in the study. No intra-procedure complications occurred. 1 patient had pneumonia during post-operative stay. 1-month overall response rate (2 CR and 10 PR) was 80%. At 3-month follow-up, 3 patients (20%) showed PD, 3 patients (20%) died from the ongoing disease, 1 patients (6.7%) died for other reasons, whereas the other patients maintained their 1-month clinical response. 8 out of 13 patients (61.5%) were alive at 6-month follow-up, whereas 6 out of 12 patients (50%) were alive at 1-year follow-up.

Abstract 435 Figure 1
Abstract 435 Figure 1

Conclusion ECT has proven to be a feasible, easy to perform, reproducible and repeatable procedure. For these reasons, it may have a role in the management of VC, especially as palliative treatment when other therapies are no longer applicable.

https://doi.org/10.1136/ijgc-2020-IGCS.377

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.