Objectives Endometrial cancer is the third most common cancer among women worldwide, although epidemiological data in Brazil is poorly known. This study aimed to describe epidemiology of endometrial cancer in a private center institution.

Methods A retrospective cohort was conducted at BP – Beneficiencia Portuguesa de Sao Paulo, Brazil from January 1st, 2010 to March 31st, 2019. Variables analyzed as age, International Federation of Gynecology and Obstetrics (FIGO) classification, baseline performance status, obstetrical and physical background, tobacco use, body mass index (BMI) type of treatment and outcome.

Results One hundred and twenty-seven (127) cases of endometrial cancer were diagnosed during the study period. The median age was 66 years [29–94]. The majority of patients were postmenopausal status [95%], 18% of the patients admitted tobacco use and almost 40% were obese. Endometrioid was the most frequent histology [77% - 0,43–1,00]. Most were locally advanced [FIGO II-IV] and treated with surgery associated with radiation or platinum-based chemotherapy. Despite this, with a median of 2.5 years for relapse [50% of patients], local recurrence was more frequent. On this setting, chemotherapy was the mais treatment. Only 7% of the women underwent to somatic study. Median overall survival was 6 years [1–11] and we did not find statistical significance when related to histology and risk factors.

Conclusions Endometrial cancers are diagnosed at a late stage in our cohort, which has an impact on treatment options and survival. Awareness of population for signs and symptons and screening programs need to be reinforced to insure earlier diagnosis and patient retention.